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    Hebei Huanhao Biotechnology Co.,Ltd

    Country: Country China (Mainland)

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    • Ms.Joy
    • Ms.Judith
    • Ms.Young Yang
    • Ms.Lisa
    • Ms.grace
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    • Ms.Bernice Wang

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    Tel: +86-17194018088

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    Tel: +86 18032212870

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    Tel: +8619930642939

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    Tel: +8617194018088

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  • Ms.grace
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  • Ms.Cathy
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  • Ms.Bernice Wang
    Tel: +86 19930594861

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Home > Products >  Manufacturer supply YK11/yk-11 cas 1370003-76-1

Manufacturer supply YK11/yk-11 cas 1370003-76-1 CAS NO.1370003-76-1

  • FOB Price: USD 1 /Kilogram Get Latest Price
  • Min.Order: 10 Gram
  • Payment Terms: T/T,Western Union,MoneyGram,Other
  • Available Specifications:

    AAAAA(1-100)KilogramAAAAA(1-100)Kilogram

  • Product Details

Keywords

  • YK11
  • YK-11
  • 1370003-76-1

Quick Details

  • ProName: Manufacturer supply YK11/yk-11 cas 137...
  • CasNo: 1370003-76-1
  • Molecular Formula: C14H12F6N2O
  • Appearance: A white crystal powder
  • Application: collodion ,nitrocellulose, varnish,art...
  • DeliveryTime: 3 days after payment confirmation
  • PackAge: According to your request
  • Port: Shanghai
  • ProductionCapacity: 1 Metric Ton/Month
  • Purity: more than 99.6%
  • Storage: Dry and ventilated
  • Transportation: We can send it via HKems, HK Air Post,...
  • LimitNum: 10 Gram
  • Related Substances: 0.001%
  • Residue on Ignition: 0.001%
  • Heavy Metal: 0.001%
  • Valid Period: 0.001%
  • Place of origin: China

Superiority

 

Hebei Huanhao Biotechnology co., Ltd.  is specializing in the production of research and development of pharmaceutical intermediates, this kind of products with high quality price concessions,welcomed the new and old customers advisory purchase,companies invest large fund and brain research fine chemical r&d department,biochemical,phamaceutical and intermediate products to meet the demand of the market .High level research team,advanced equipment and good scientific atmosphere ensure the quality .

We now the biggest product base ,UV series products in the east of China .In addition,one of our main chemical expoters of jiangsu province.Our products sell well in Italy,South Korea,Canada,Poland ,Austrilia,Britain ,Mexico,Germany,the United States,and so on .

Superiority

Our company product advantage:
1.ample supply and prompt delivery
2.goods of every description are available.
3.Rich experience in industry
4.superior quality and reasonable price
5.selling well all over the world
6.We can customize product according to demand
 
Our company advantage:
1. Best quality in your requirement
2. Competitive price in China marke
3. mature Technical support
4. Professional logistic support
5 .Full experience of large numbers containers loading in Chinese sea port
6. Fast shipment by reputed shipping line 
 
 
 

Details

Product Name:mmaf

  CAS Number: 745017-94-1

  Purity:≥99.6%

  Appearance: powder

  Molecular formula: C18H23FN2O

  Molecular weight: 302.39

  Best quality in your requirement

  Competitive price in China market

  Mature technical support

  Professional logistic support

  Loading in Chinese sea port

  Packing with pallet as buyer's special request

  Best service after shipment with e-mail

  Full experience in export

  Raw materials from Chinese origin

  Some products exports to U.S.A, the Netherlands , Poland,Canada,England,Italy ,Columbia and so on.

 

Products can be customized according to customer demand .

 

 

Details


 Use of YK11

YK11 is a partial agonist of androgen receptor, with osteogenic activity.

 Names

Name YK-11
Synonym More Synonyms

 YK11 Biological Activity

Description YK11 is a partial agonist of androgen receptor, with osteogenic activity.
Related Catalog
Target

Androgen receptor[1]

In Vitro YK11 is a partial agonist of androgen receptor, and induces myogenic differentiation of C2C12 Cells at 500 nM via Fst mRNA upregulation by AR. YK11 enhances Myf5 and myogenin mRNA expression, but requires high concentrations (YK11, 100 nM or 500 nM)[1]. YK11 (0.5 µM) increases the cell growth of osteoblastic MC3T3-E1 cells, and enhances ALP activity via AR. YK11 also elevates osteoprotegerin mRNA expression (0.5 µM) and dose-dependently increases osteocalcin mRNA expression (0.1-1.0 µM). In addition, YK11 enhances phosphorylation of Akt protein via rapid non-genomic signaling[2].
Cell Assay Mouse myoblast C2C12 cells are cultured in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% fetal bovine serum (FBS) at 37°C in a humidified atmosphere with 5% CO2. C2C12 cells are seeded on plates and maintained in culture medium for 24 h. To induce myogenic differentiation, YK11 or DHT in DMEM supplemented with 2% horse serum (differentiation medium) is added to the cells on day 0. For the neutralization assay of Fst (also known as activin-binding protein), C2C12 cells are maintained in differentiation medium in the presence of anti-Fst antibody[1].
References

[1]. Kanno Y, et al. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biol Pharm Bull. 2013;36(9):1460-5.

[2]. Yatsu T, et al. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells. Biol Pharm Bull. 2018;41(3):394-398.

 Chemical & Physical Properties

Molecular Formula C25H34O6
Molecular Weight 430.541
Exact Mass 430.236

 Synonyms

YK11

1.We have been exporting for more than 15 years

2.Have professional employees and efficient management

3.Excellence Service and fast delivery

4.Sample are available,Small quantity is welcomed.

 

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